What's the matter? *用于对方身体不舒服或对方有什么异常时。
What's the matter? You look sad. (你怎么了?显得这么伤心。)
Nothing. I'm just tired. (没什么。我只是累了。)
Is anything wrong?
What's the problem?
Is something bothering you? *bother “使……烦心”、“折磨”。
Are you okay? *用于对方发生什么不好的事情时。
Are you all right?
What's going on?
What's going on? (到底怎么回事?)
We were just talking. (我们只是说说。)
Is something on your mind? *be on a person's mind “有什么挂心的事”。
Do you have something on your mind?
What are you worried about? (你担心什么?)
What's on your mind? (你担心什么呢?)
Is anything bothering you?
I was worried about you.
I was concerned about you.
Please don't go out of your way.
I'll drop you off. (我送你回家。)
Please don't go out of your way. (请不要特地送我。)
You look serious.
You look serious. (你怎么那么严肃。)
This is important. (这事很重要。)
You look grave.
You look sad today.
You don't look very happy today.
Why are you so glum? *glum “闷闷不乐的”、“忧郁的”、“愁闷的”。
Why are you so glum? (你怎么闷闷不乐的呀?)
My girlfriend just dumped me. (女朋友刚跟我吹了。)*dump “抛弃”。
Why so glum?
Why the long face?
You look exhausted. *exhausted “精疲力尽”、“疲劳不堪”，表示在此情况下再也不能做任何事情的疲劳感。
You look very tired.
You look worn-out.
You look bushed. *俚语。
You look pooped. *俚语。
You need a break.
It's six o'clock already. (已经6点了。)
Yeah, you need a break. (是呀，你该休息会儿了。)
You need a rest.
You need to take a break.
You should take it easy. (你该放松会儿。)
Something is wrong with you today.
You're not yourself today.
You seem different today.
Who are you irritated with? *用be irritated with...表示“为……而急躁的”、“为……而发怒的”。
Who has irritated you?
I think you're nervous. (我觉得你太紧张。)
No, I'm not nervous! (没有，我不紧张。)
You seem nervous. (你好像很紧张。)