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߱㹻йع涨Ҫ1824Ҫʱ
αƼ
öȺЧовαƼաαƼİȫԺЧӦúϸñ£¬²Î±Æ¼Ñ¡ÔΪоöоʱѡеľעΪαƼöȻЧоʱӦѡͬƷΪαƼ
Ƽ
ƼӦΪٴӦ׼ķŴƷṩܳȡȶԡЧ۵ݡҩṩྦྷͼѧ칹ϡ
Ä£
ƼһΪƼһΪαƼͨ˫ƼƣԵں͸Ӱ졣ֳ飬һȷƼòαƼһȷòαƼƼ֮ΪϴڣϴӦҩ10˥ڣͨΪ1ܻ2ܡ
3ƼƼһαƼʱ˲3Ƽ3ڵĶ3×3ʽơÿ֮ϴͨΪ1Ü»2Ü¡
ȡ㣺ȡƶĿɿҪáҩǰȡհѪһѪҩŨ-ʱӦࡢֲࡣһѪҩŨ-ʱ߷ǰȡ4㣬ȡ66ϵĵ㣬ʱ丽Ӧ㹻ȡ㣬ܲհף12㡣ȡ35˥ڻѪҩŨΪCmax1/101/20.
ڲѪҩŨȲⶨʱɲƷвⶨҺҩƷ鷽ӦöȲⶨҪ󡣣ҽѧ Ѽ
壩ҩȷ
öЧоʱҩһӦٴҩһ¡ƼͲαƼӦõȼʹòȼʱӦ˵Ôҩڴ˼ΧڷԶѧɣöʱӦԼУ
о
߽ʳҹ10Сʱϣڴ糿ոƼαƼ250ml¿ˮͷҩ2Сʱ󷽿ˮ4Сʱͳһ׼͡ڷҩ󣬰ҪڲͬʱȡѪҪȡѪѪѪȫѪ䶳棬⡣߷ҩһȡѪٴ໤нСвӦʱӦӦʩҪʱӦֹͣ顣
ߣҩﶯѧ
õĸ߲ͬʱƷѪҩŨݼƽֵ׼бͼȻֱԸ߽йҩﶯѧ㣬ƽֵͱ׼ҪҩﶯѧΪ˥ڣt1/2ŨȣCmaxʱ䣨TmaxѪҩŨȪʱAUC.CmaxTmaxʵֵʾơAUC0tn㵽tʱѪҩŨ-ʱηη㣬tnһοɲŨȵȡʱ䡣AUC0ޣ㵽޴ʱѪҩŨ-ʱʽ㣬AUC0=AUC0tn+Ctn/z.CtnһѪҩŨȣzĩٶȳt1/2=0.693/zzöѪҩŨȪʱĩֱֵ߲бá
ö飬ҪʱղѪ㣨AUC0tn/AUC0Þ£×100%80%.
ˣöȼ
1θҩ
öFӦøߵAUC0tnAUC0޷ֱ㣬ֵ׼ƼTͲαƼRͬʱ
F=AUC0tnT/AUC0tnR×100%F=AUC0Þ£T/AUC0Þ£R×100%
ҩҩﶯѧʱƼͲαƼҲɲòͬʽУ
F=AUC0tnT×DR/AUC0tnR×DT×100%F=AUC0Þ£T×DR/AUC0Þ£R×DT×100%
ʽУDRΪαƼĸҩDTΪƼĸҩƼͲαƼҩļӦʵ⺬㡣
лݣǰҩҩڴл죬޷ⶨѪÔҩʱɲӦĻԴлöо
öȵļAUC0tnΪοAUC0ޡ
2θҩ
£ɿǶθҩ̬̬ѪҩŨȹöȣ1ҩճ̶󣬵ٶнϴ죻2öȸ󣻣3͡Ƽ4θҩÔҩлŨȺܵͣӦķ׼ȷá
θҩȼӣҩ̬ijһҩʱڣβɼƷҩŨȣ̬ڼ0ʱѪҩŨ-ʱµAUCSSƼͲαƼʱʽö
F=AUCSSTAUCSSR×100%
ʽУAUCSSTAUCSSRֱƼαƼ̬µAUC.
ţЧۣҩﶯѧͳƷ
ӦҩﶯѧҪAUCCmaxͳƷЧۡͳƷȽAUCCmaxݽжתȻз˫t鴦ƼAUC90%ڲαƼ80%125%ΧڣCmaxڲαƼ70%143%ΧڣΪƼαƼЧTmax÷Dzм顣
Ϊ˱ЧԱȽϣÿһ߷òͬƼҩﶯѧAUCCmaxӦƽбҪгƼTͲαƼR֮ıֵT/RͱֵĶ˼ǵֵ⣬Ӧü㼸ξֵӦðڱС
ʮٴ桢úͲӦ
߲ʷͻԼоصĿܸúͲӦӦ档

