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Ŀ߿ո£ȽƼαƼʺճ̶ȣȷԻ͡ƼαƼǷΪЧл͡
1Ҫѡ
ͬͨƼ
2αƼ
һӦѡùͬеĻ͡ƼƷΪαƼϵµĻ͡ƼӦѡеͬͨƼƷΪαƼ
3
ͬͨƼθҩ
4ṩ
1гߵѪҩŨ-ʱݡѪҩŨƽֵбͼ
2ҩﶯѧƽֵCmaxTmaxAUC0tnAUC0Fṩƽʱ䣨MRTȡ
3ٴ桢úͲӦͨƼҪͬ
5Ч
Ի͡ƼαȻ͡ƼȽϣAUCCmaxЧҪTmaxͳӦ죬ΪƼЧԻ͡ƼͨƼȽϣAUCЧҪͬͨƼAUCЧۣΪճ̶ЧCmaxͣTmaxӳţͳƷһָ겻ЧʱƼлͻ
θҩ˫ڽ
ĿоԻ͡ƼαƼθҩ̶̬Լ̬ѪҩŨȵIJ
1Ҫѡ
ͬ£ɼõߡΪ1824ҪʱʵӡαƼͬθҩ
2Ƽ
ƷηƼαƼƼⶨҩͷÿ1ҩƼӦڿո10СʱԺҩҩʳ24Сʱÿ2εƼӦո10СʱԺҩҩʳ24СʱڶӦڲǰͺ2Сʱҩҩʳ2Сʱÿ250ml¿ˮͷһҪҩ12СʱˮͨƼΪαƼʱҩ뷽Ӧ뻺͡Ƽÿܼȡ
3ȡ
ҩʱپ7˥ںⶨ3ĹŨȣCminȷѪҩŨǷ̬ȡðڲͬͬһʱ䣨һ峿ԵʱҩѧӰ죬ұڱȽϡ̬һڣյθҩʱƣȡ㹻Ѫ㣬ⶨü̬ѪҩŨȪʱݣйصҩﶯѧŨȡʱ䡢̬ƽѪҩŨȣCavAUCSSȡ
4ҩﶯѧݴ
1гߵѪҩŨȪʱݡѪҩŨƽֵбͼ
2ߵCmaxCminTmaxCavAUCSSƽֵCmaxTmaxʵֵCminһ㰴һҩǰʱʵŨȵƽֵ㣬AUCSSη㡣
̬ƽѪҩŨȿʽ
Cav=AUCSS
ʽУAUCSS̬ڼ0ʱѪҩŨ-ʱµǷҩʱ䡣
3̬ʱö
F=AUCSST/AUCSSR×100%F=AUCSST×DR/AUCSSR×DT×100%
4ѪҩŨȵIJDF%ʽ
DF=Cmax-Cmin/Cav×100%
ʽУCmax̬ҩڼһҩʵҩŨֵCmin̬ҩڼһҩʵĹŨȡαƼΪƼʱƼDF/ֵΪڲαƼDF/ֵ143%αƼΪͨƼʱƼDF/ֵӦСͨƼ
5ͳѧЧ
뻺͡ƼθҩķҪͬ
6ٴ桢úͲӦ
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