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Ŀ߿ո£ȽƼαƼʺճ̶ȣȷԻ͡ƼαƼǷΪЧл͡
1Ҫѡ׼
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2αƼ
һӦѡùͬеĻ͡ƼƷΪαƼϵµĻ͡ƼӦѡеͬͨƼƷΪαƼ
3
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4ṩ
1гߵѪҩŨ-ʱݡѪҩŨƽֵ׼бͼ
2ҩﶯѧƽֵ׼CmaxTmaxAUC0tnAUC0޺Fṩƽʱ䣨MRTȡ
3ٴ桢úͲӦͨƼҪͬ
5Ч
Ի͡ƼαȻ͡ƼȽϣAUCCmaxЧҪTmaxͳӦ죬ΪƼЧԻ͡ƼͨƼȽϣAUCЧҪͬͨƼAUCЧۣΪճ̶ЧCmaxͣTmaxӳţͳƷһָ겻ЧʱƼлͻ
θҩ˫ڽ
ĿоԻ͡ƼαƼθҩ̶̬Լ̬ѪҩŨȵIJ
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ͬ£ɼõߡΪ1824ҪʱʵӡαƼͬθҩ
2Ƽ
ƷηƼαƼƼⶨҩͷÿ1ҩƼӦڿո10СʱԺ󳿼ҩҩʳ24Сʱÿ2εƼ׼Ӧո10СʱԺҩҩʳ24СʱڶӦڲǰͺ2Сʱҩҩʳ2Сʱÿ250ml¿ˮͷһҪҩ12Сʱ󣬷ˮͨƼΪαƼʱҩ뷽Ӧ뻺͡Ƽÿܼȡ
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4ҩﶯѧݴ
1гߵѪҩŨȪʱݡѪҩŨƽֵ׼бͼ
2ߵCmaxCminTmaxCavAUCSSƽֵ׼CmaxTmaxʵֵCminһ㰴һҩǰʱʵŨȵƽֵ㣬AUCSSη㡣
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Cav=AUCSS
ʽУAUCSS̬ڼ0ʱѪҩŨ-ʱµǷҩʱ䡣
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5ͳѧЧ
뻺͡ƼθҩķҪͬ
6ٴ桢úͲӦ
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